DUAL-REGISTERED PROTOCOL // OSF PRE-REGISTERED (DOI: 10.17605/OSF.IO/VPS9D) · CLINICALTRIALS.GOV PRS IN PROGRESS · PROTOCOL ID: DS-CLIN-2026-CARDIO-RESOLVE · PLANNED N = 10,000
CARDIO-RESOLVE™ Registry.
Precision cardiology meets autonomic resilience.
From monogenic channelopathies to the exploding pandemic of post-viral dysautonomia and POTS, traditional cardiology relies on fragmented snapshot testing. CARDIO-RESOLVE™ is a prospective decentralized clinical registry ($N=10,000$) uniting advanced lipidomics, continuous autonomic hemodynamics, and cardiac ion channel genomics under the DeepSensi Cognitive Engine. Participation in the clinical registry is 100% Free.
RESOLVE in the United States: in preparation (IRB submission in preparation, the first country to open).
Registry Strata
Three Specialized Cardiovascular Cohorts
Postural Orthostatic Tachycardia (POTS) & Dysautonomia
Post-viral autonomic dysfunction, orthostatic intolerance, and small-fiber neuropathy. Serial tracking of supine/standing plasma catecholamines (norepinephrine, epinephrine), renin-aldosterone ratio, and autonomic heart-rate variability under DSS-001.
Hereditary Cardiomyopathies (HCM, DCM, ARVC)
Sarcomeric and structural genetic variants (*TTN, MYBPC3, MYH7, LMNA*). Modeling subclinical myocardial strain, serial high-sensitivity troponin (hs-cTnI), and NT-proBNP kinetic progression curves.
Primary Channelopathies & Refractory Dyslipidemia
Long QT Syndrome (*KCNQ1, KCNH2, SCN5A*), Brugada Syndrome, and Familial Hypercholesterolemia (FH). Advanced particle lipidomics (Lp(a), ApoB, LDL-P) and ion-channel drug safety tensors.
Biomarkers & Outcomes
Hemodynamic & Molecular Primary Endpoints
Orthostatic Tolerance & COMPASS-31
Documented stabilization of orthostatic heart-rate delta and statistically significant reduction in autonomic symptom burden on the COMPASS-31 and Orthostatic Hypotension Questionnaire (OHQ).
Biomarker Normalization (NT-proBNP & hs-cTnI)
Quantitative reduction and stabilization of myocardial stress markers and lipid particle burden under physician co-signed metabolic and cardiovascular supportive protocols.
QTc & Arrhythmic Safety Governance
Continuous algorithm-assisted auditing of concomitant medications for additive QTc-prolongation risk and cytochrome P450 competitive clearance bottlenecks.
DeepSensi DCT
