DUAL-REGISTERED PROTOCOL // OSF PRE-REGISTERED (DOI: 10.17605/OSF.IO/VPS9D) · CLINICALTRIALS.GOV PRS IN PROGRESS · PROTOCOL ID: DS-CLIN-2026-ENDO-RESOLVE · PLANNED N = 10,000
ENDO-RESOLVE™ Registry.
Closing the 7-10 year diagnostic void.
Endometriosis and complex hormonal-immune syndromes afflict over 190 million women worldwide. Yet modern medicine traps patients in a 7-to-10 year diagnostic delay, bouncing between gynecology, gastroenterology, and pain clinics while systemic peritoneal neuro-inflammation, cytokine remodeling, and estrogen-microbiome axes remain unaddressed. ENDO-RESOLVE™ is a global decentralized clinical registry ($N=10,000$) uniting the DeepSensi Cognitive Engine with multi-omics phenotyping. Participation in the registry is 100% Free.
RESOLVE in the United States: in preparation (IRB submission in preparation, the first country to open).
Core DeepSensi Specialization
Difficult Cases, Cross-Domain Systems Biology & The "Inter-Specialty White Space"
Why Endometriosis is Not Merely a "Gynecological" Disease
Endometriosis is the quintessential victim of medical departmentalization. The gynecologist excises visible lesions; the gastroenterologist diagnoses refractory IBS; the urologist notes sterile interstitial cystitis; the rheumatologist sees unexplained autoimmunity. DeepSensi bridges the inter-specialty white space by resolving the systemic multi-organ feedback loop: estrogen-metabolizing estrobolome dysbiosis, peritoneal macrophage dysfunction, peripheral nerve sensitization, and mitochondrial bioenergetic exhaustion. We treat the organism as an integrated network, not isolated organs.
Registry Strata
Three Specialized Clinical Cohorts
Deep Infiltrating Endometriosis (DIE)
Extrapelvic, bowel, bladder, and diaphragmatic endometriosis refractory to hormonal suppression (GnRH antagonists, progestins) and repetitive laparoscopic excisions. Tracking neuro-angiogenesis and fibrotic tensor progression.
Adenomyosis & Pelvic Central Sensitization
Myometrial junctional zone expansion, intractable dysmenorrhea, and secondary pelvic neuropathic allodynia. Resolving the crosstalk between microglial priming in the spinal dorsal horn and uterine natural killer (uNK) cell dysregulation.
Metabolic-Immune Refractory PCOS & POI
Severe polycystic ovary syndrome resistant to standard insulin-sensitizers and lifestyle modifications, coupled with premature ovarian insufficiency (POI). Mapping hyperandrogenic mitochondrial stress and systemic low-grade endotoxemia.
From routine care, ordered by each participant's own physicians, the registry also records a metagenomic stool profile.
Clinical Endpoints
Primary & Exploratory Biomarker Endpoints
EHP-30 & Biberoglu-Behrman Score
Statistically significant reduction (≥ 35%) in non-menstrual pelvic pain, dyschezia, and dyspareunia without reliance on continuous opioid or central sedative escalation.
Peritoneal & Serum Cytokine Tensor
Longitudinal normalization of inflammatory mediator panels (IL-1β, IL-6, TNF-α, VEGF-A, and CA-125 kinetics) correlated with intestinal permeability (zonulin) and microbiome estrobolome biodiversity.
Avoidance of Repeat Laparoscopic Surgeries
Reduction in surgical intervention frequency and ovarian reserve preservation (AMH stability) through root-cause immunomodulation and non-invasive DSS-001 longitudinal monitoring.
Join the ENDO-RESOLVE™ Registry
Are you a clinician caring for complex endometriosis or a patient navigating intractable symptoms? Enrollment in our prospective decentralized observational registry is completely free.
DeepSensi DCT
