DUAL-REGISTERED PROTOCOL // OSF PRE-REGISTERED (DOI: 10.17605/OSF.IO/VPS9D) · CLINICALTRIALS.GOV PRS IN PROGRESS · PROTOCOL ID: DS-CLIN-2026-NEURO-RESOLVE · PLANNED N = 10,000
NEURO-RESOLVE™ Registry.
Resolving neuroinflammatory & post-viral cascades.
Regressive Autism Spectrum Disorder (ASD), PANS/PANDAS, ME/CFS, and Neuro Long COVID share deep underlying neuro-immune disruptions. NEURO-RESOLVE™ is a prospective decentralized clinical registry ($N=10,000$) tracking tryptophan-kynurenine diversion, cerebral folate transport, and microglial activation under the DeepSensi Cognitive Engine. Participation in the clinical registry is 100% Free.
RESOLVE in the United States: in preparation (IRB submission in preparation, the first country to open).
Registry Strata
Three Core Neuro-Immune Pathology Cohorts
Regressive Autism Spectrum Disorder (ASD)
Children with developmental stagnation or regression, severe gut dysbiosis, mitochondrial dysfunction, and cerebral folate autoantibodies.
PANDAS / PANS & Basal Ganglia Autoimmunity
Acute-onset OCD, motor/vocal tics, severe anxiety, and autoimmune encephalopathy triggered by streptococcal or post-viral infections.
ME/CFS & Neuro Long COVID
Post-viral brain fog, microglial neuroinflammation, postural orthostatic intolerance, and profound post-exertional neuro-immune exhaustion.
From routine care, ordered by each participant's own physicians, the registry also records urine organic acids and a metagenomic stool profile, through which it observes the gut-brain axis.
DeepSensi DCT
